Enfamil® Optimum™ (Enspire) Infant Formula - Powder - 20.5 oz Tub - Online | Enfamil
For our nutrition closest to breast milk
Makes approx. 33 servings (4 fl oz bottles)
Earns 480 rewards points with purchase
Enfamil Optimum (Enspire) Infant Formula
Introducing Enfamil Optimum, formerly known as Enfamil Enspire Optimum—now with a fresh new look but the same trusted nutrition for your little one.
Enfamil Optimum is designed to be our closest formula to breast milk, it has lactoferrin, a key protein found in colostrum and breast milk, and a dual HMO blend.
Perfect for combo feeding, Enfamil Optimum is ideal for supplementing breastfeeding, ensuring your baby gets essential nutrients while providing parents with convenience and peace of mind.
Enfamil Optimum has 2'FL & LnNT, two of the most abundant HMOs that are naturally present in breastmilk, to nourish their immune health.
With NO artificial growth hormones, NO artificial colors or flavors, and a NON-GMO* formula, Enfamil Optimum has complete nutrition for babies through 12 months. Give your baby the best start with Enfamil—trusted by parents†, backed by science.
*Added as an ingredient.
†Not made with genetically modified ingredients, but trace amounts of genetically engineered materials may be present in the product from manufacturing environments and process sources.
‡Among those who have a preference; based on the 2023 survey by AMC Global.
Available Formats and Sizes
Enfamil Optimum Infant Formula is available in powder form in tubs of 20.5 oz and 27.4 oz for your convenience and 30 oz refill boxes with 100% recycled paperboard to help us reduce environmental impact. You can also get Enfamil Optimum Infant Formula in cases of 4.
NEW LOOK, SAME TRUSTED FORMULA: Enfamil Optimum, formerly Enspire Optimum, has a fresh new name and look, while offering the same great nutrition for your little one.
OUR CLOSEST FORMULA TO BREAST MILK: Enfamil Optimum is the first and only leading brand to have lactoferrin*, also found in breastmilk & colostrum.
PERFECT FOR COMBO FEEDING: Ideal for supplementing breastfeeding, Enfamil Optimum offers essential nutrients for baby while giving parents peace of mind and convenience.
PREMIUM IMMUNE BLEND: Lactoferrin and a dual HMO blend (2'FL & LnNT), key ingredients clinically shown to support baby's developing immune system.
PEACE OF MIND: Optimum contains NO artificial growth hormones, NO artificial colors or flavors, and is NON-GMO, offering complete nutrition for babies through 12 months.
TRUSTED BY PARENTS & PEDIATRICIANS†: Enfamil is the #1 Trusted Infant Formula Brand By Pediatricians† & Parents and the #1 trusted brand by pediatricians for brain-building and Immune Support.
Enfamil reduces its environmental impact by using 100% recycled paperboard for our refill boxes.
Nonfat Milk, Lactose, Vegetable Oil (contains one or more of the following: Palm Olein Oil, Coconut Oil, Soy Oil, High Oleic Sunflower Oil), Whey Protein Concentrate*, and less than 2%: Lacto-N-neotetraose†, 2'-Fucosyllactose†, Lactoferrin, Mortierella Alpina Oil‡, Schizochytrium Sp. Oil§, Carbonate, Phosphate, Cupric Sulfate, Ferrous Sulfate, Magnesium Oxide, Manganese Sulfate, Potassium Chloride, Potassium Citrate, Potassium Iodide, Sodium Chloride, Sodium Selenite, Zinc Sulfate, Soy Lecithin, Chloride, , Ascorbic Acid, Biotin, Pantothenate, Folic Acid, Niacinamide, Riboflavin, Thiamin Hydrochloride, Vitamin B12, Vitamin B6 Hydrochloride, Vitamin D3, Vitamin K1, Vitamin E Acetate, Vitamin A Palmitate, Taurine, L-carnitine.
Milk and protein sources that have a balanced combination of proteins and carbohydrates for necessary nutrients.
Palm olein, coconut, soy, and high oleic sunflower oils have important fats for infant growth and development.
Lacto-N-neotetraose (LNnT) and 2'-Fucosyllactose (2'-FL) are compounds also naturally found in breast milk.
A protein, also found in breast milk, that helps support the immune system.
Sources of & , they are important for brain and eye development.
Source of to support bone health.
Essential minerals to support bone development, nerve function, and cellular activities.
Acts as an emulsifier for improved formula texture.
Important nutrients to support brain development and overall growth.
Essential for immune support, bone health, and overall growth.
Playing important roles in central nervous system development and energy metabolism.
A source Of (Milk Fat Globule Membrane composed of proteins and fats) components
A source Of HMO (2'-FL & LNnT Human Milk Oligosaccharides)
A source Of Arachidonic Acid ()
A source Of Docosahexaenoic Acid ()
Please refer to your product packaging for the most accurate information.
Last Updated: 7/17/25
Nutrients
(Normal Dilution); per 100 Calories (5 fl oz)
Protein 2.1 g
Fat 5.3 g
Carbohydrate 11.1 g
Water 133 g
Linoleic acid 780 mg
Vitamins
(Normal Dilution); per 100 Calories (5 fl oz)
Vitamin A 300 IU
Vitamin D 70 IU
Vitamin E 2 IU
Vitamin K 9 mcg
Thiamin (Vitamin B1) 80 mcg
Riboflavin (Vitamin B2) 140 mcg
Vitamin B6 60 mcg
Vitamin B12 0.3 mcg
Niacin 1000 mcg
Folic acid (Folacin) 16 mcg
Pantothenic acid 500 mcg
Biotin 3 mcg
Vitamin C (Ascorbic acid) 12 mg
Choline 24 mg
Inositol 24 mg
Minerals
(Normal Dilution); per 100 Calories (5 fl oz)
Calcium 78 mg
Phosphorus 43 mg
Magnesium 8 mg
Iron 1.8 mg
Zinc 1 mg
Manganese 15 mcg
Copper 75 mcg
Iodine 15 mcg
Selenium 2.8 mcg
Sodium 27 mg
Potassium 108 mg
Chloride 63 mg
Please refer to your product packaging for the most accurate information.
Last Updated: 1/21/25
Your baby's health depends on carefully following the instructions below. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Powdered infant formulas are not sterile and should not be fed to premature infants or infants who might have immune problems unless directed and supervised by your baby's doctor. Ask your baby's doctor which formula is appropriate for your baby. Ask your baby's doctor about the need to use cooled, boiled water for mixing and the need to boil clean utensils, bottles and nipples in water before use.
Wash hands thoroughly with soap & water before preparing formula.
Pour desired amount of water into the bottle. Add powder.
Cap bottle and SHAKE WELL.
Use the chart below for correct amounts of water and powder. Use scoop in tub to measure powder. Store DRY scoop in lid holder.
| To Make* | Water | Powder |
|---|---|---|
| 2 fl oz bottle | 2 fl oz | 1 unpacked level scoop (8.8 g) |
| 4 fl oz bottle | 4 fl oz | 2 unpacked level scoops (17.6 g) |
| 8 fl oz bottle | 8 fl oz | 4 unpacked level scoops (35.2 g) |
*Each scoop adds about 0.2 fl oz to the amount of prepared formula.
WARNING: Do not use a microwave oven to warm formula. Serious burns may result.
Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use formula within one hour or discard.
Storage/Handling: Store powder at room temperature; avoid extreme temperatures. After opening, keep pouch and tub lid tightly closed, store in a dry area, and use contents within 1 month. Use tub with Enfamil Optimum formula only. Keep powder fresh and prevent bacterial growth by assuring tub is clean and completely dry. When using refill pouches, remove the empty pouch and wipe tub with a clean, dry cloth.
Place new refill pouch inside the tub and keep the powder in the pouch.
Always refer to the batch code and "use by" date on the refill pouch.
Last updated: 8/18/25
Formula benefits
Non-GMO
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Enfamil® Optimum™ (Enspire) Infant Formula