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Enfamil® Optimum™ (Enspire) Infant Formula - Powder - 30 oz Refill Box - Online | Enfamil

Enfamil Optimum Infant Formula Refill Box 30oz
New name! same premium formula. packaging may vary
Enfamil Optimum Infant Formula Refill Box 30oz back image
Nutrients, Vitamins, Minerals, Ingredients & Instructions for preparation & use
Enfamil Optimum Infant Formula Refill Box 30oz side image
Our Next Breast Thing. Optimum is our closest to breast milk
No one way. Just your way with Optimum. Perfect for combo-feeding
Enfamil Optimum brings you components also found in your breast milk
More time for what matters most. Ready-to-feed convenience for every routine
A formula or every feeding style. Try all Optimum formats
Lactoferrin LnNT 2'FL DHA
Clinically tested ingredients, parent trusted. 120 years of heritage.
Nourish 5-in-1 benefits to support: Immune health Gut health Motor skills Attention span Communication development
Nutrients, Vitamins, Minerals & Ingredients
Makes 48 4fl oz bottles
Onebrand100% Recyclable Paperboard

Enfamil® Optimum™ (Enspire) Infant Formula Powder - 30 oz Refill Box

For our nutrition closest to breast milk

Makes approx. 48 servings (4 fl oz bottles)

$64.49
In Stock
Earn Star

Earns 645 rewards points with purchase

Format

Format
Powder

Type

Tub
Refill

Size

30 oz Refill Box

$0.30 per fl oz

$64.49

Ships free

30 oz Refill Box (Case of 4)

$0.29 per fl oz

$251.96

Ships free
Best value
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Enfamil Optimum Infant Formula Refill Box 30oz

Enfamil® Optimum™ (Enspire) Infant Formula

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Enfamil Optimum (Enspire) Infant Formula

Introducing Enfamil Optimum, formerly known as Enfamil Enspire Optimum—now with a fresh new look but the same trusted nutrition for your little one.

Enfamil Optimum is designed to be our closest formula to breast milk, it has lactoferrin, a key protein found in colostrum and breast milk, and a dual HMO blend.

Perfect for combo feeding, Enfamil Optimum is ideal for supplementing breastfeeding, ensuring your baby gets essential nutrients while providing parents with convenience and peace of mind.

Enfamil Optimum has 2'FL & LnNT, two of the most abundant HMOs that are naturally present in breastmilk, to nourish their immune health.

With NO artificial growth hormones, NO artificial colors or flavors, and a NON-GMO* formula, Enfamil Optimum has complete nutrition for babies through 12 months. Give your baby the best start with Enfamil—trusted by parents†, backed by science.

*Added as an ingredient.

†Not made with genetically modified ingredients, but trace amounts of genetically engineered materials may be present in the product from manufacturing environments and process sources.

‡Among those who have a preference; based on the 2023 survey by AMC Global.

Available Formats and Sizes

Enfamil Optimum Infant Formula is available in powder form in tubs of 20.5 oz and 27.4 oz for your convenience and 30 oz refill boxes with 100% recycled paperboard to help us reduce environmental impact. You can also get Enfamil Optimum Infant Formula in cases of 4.

NEW LOOK, SAME TRUSTED FORMULA: Enfamil Optimum, formerly Enspire Optimum, has a fresh new name and look, while offering the same great nutrition for your little one.
OUR CLOSEST FORMULA TO BREAST MILK: Enfamil Optimum is the first and only leading brand to have lactoferrin*, also found in breastmilk & colostrum.
PERFECT FOR COMBO FEEDING: Ideal for supplementing breastfeeding, Enfamil Optimum offers essential nutrients for baby while giving parents peace of mind and convenience.
PREMIUM IMMUNE BLEND: Lactoferrin and a dual HMO blend (2'FL & LnNT), key ingredients clinically shown to support baby's developing immune system.
PEACE OF MIND: Optimum contains NO artificial growth hormones, NO artificial colors or flavors, and is NON-GMO, offering complete nutrition for babies through 12 months.
Pediatrician Recommended
TRUSTED BY PARENTS & PEDIATRICIANS†: Enfamil is the #1 Trusted Infant Formula Brand By Pediatricians† & Parents and the #1 trusted brand by pediatricians for brain-building and Immune Support.
Enfamil reduces its environmental impact by using 100% recycled paperboard for our refill boxes.
Nonfat Milk, Lactose, Vegetable Oil (contains one or more of the following: Palm Olein Oil, Coconut Oil, Soy Oil, High Oleic Sunflower Oil), Whey Protein Concentrate*, and less than 2%: Lacto-N-neotetraose†, 2'-Fucosyllactose†, Lactoferrin, Mortierella Alpina Oil‡, Schizochytrium Sp. Oil§, Carbonate, Phosphate, Cupric Sulfate, Ferrous Sulfate, Magnesium Oxide, Manganese Sulfate, Potassium Chloride, Potassium Citrate, Potassium Iodide, Sodium Chloride, Sodium Selenite, Zinc Sulfate, Soy Lecithin, Chloride, , Ascorbic Acid, Biotin, Pantothenate, Folic Acid, Niacinamide, Riboflavin, Thiamin Hydrochloride, Vitamin B12, Vitamin B6 Hydrochloride, Vitamin D3, Vitamin K1, Vitamin E Acetate, Vitamin A Palmitate, Taurine, L-carnitine.

Nonfat Milk, Lactose & Whey Protein Concentrate:
Milk and protein sources that have a balanced combination of proteins and carbohydrates for necessary nutrients.

Plant-based Oils:
Palm olein, coconut, soy, and high oleic sunflower oils have important fats for infant growth and development.

Dual Human Milk Oligosaccharides (HMOs):
Lacto-N-neotetraose (LNnT) and 2'-Fucosyllactose (2'-FL) are compounds also naturally found in breast milk.

Lactoferrin:
A protein, also found in breast milk, that helps support the immune system.

Mortierella Alpina & Schizochytrium Sp. Oils:
Sources of & , they are important for brain and eye development.

Carbonate:
Source of to support bone health.

Essential Minerals:
Essential minerals to support bone development, nerve function, and cellular activities.

Soy Lecithin:
Acts as an emulsifier for improved formula texture.

Chloride & :
Important nutrients to support brain development and overall growth.

Essential Vitmains:
Essential for immune support, bone health, and overall growth.

Amino Acids & Compounds:
Playing important roles in central nervous system development and energy metabolism.

* A source Of (Milk Fat Globule Membrane composed of proteins and fats) components

† A source Of HMO (2'-FL & LNnT Human Milk Oligosaccharides)

‡ A source Of Arachidonic Acid ()

§ A source Of Docosahexaenoic Acid ()

Please refer to your product packaging for the most accurate information.

Last Updated: 7/17/25

Nutrients

  (Normal Dilution); per 100 Calories (5 fl oz)
Protein 2.1 g
Fat 5.3 g
Carbohydrate 11.1 g
Water 133 g
Linoleic acid 780 mg

Vitamins

  (Normal Dilution); per 100 Calories (5 fl oz)
Vitamin A 300 IU
Vitamin D 70 IU
Vitamin E 2 IU
Vitamin K 9 mcg
Thiamin (Vitamin B1) 80 mcg
Riboflavin (Vitamin B2) 140 mcg
Vitamin B6 60 mcg
Vitamin B12 0.3 mcg
Niacin 1000 mcg
Folic acid (Folacin) 16 mcg
Pantothenic acid 500 mcg
Biotin 3 mcg
Vitamin C (Ascorbic acid) 12 mg
Choline 24 mg
Inositol 24 mg

Minerals

  (Normal Dilution); per 100 Calories (5 fl oz)
Calcium 78 mg
Phosphorus 43 mg
Magnesium 8 mg
Iron 1.8 mg
Zinc 1 mg
Manganese 15 mcg
Copper 75 mcg
Iodine 15 mcg
Selenium 2.8 mcg
Sodium 27 mg
Potassium 108 mg
Chloride 63 mg

Please refer to your product packaging for the most accurate information.

Last Updated: 1/21/25

Your baby's health depends on carefully following the instructions below. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula. Powdered infant formulas are not sterile and should not be fed to premature infants or infants who might have immune problems unless directed and supervised by your baby's doctor. Ask your baby's doctor which formula is appropriate for your baby. Ask your baby's doctor about the need to use cooled, boiled water for mixing and the need to boil clean utensils, bottles and nipples in water before use.

Wash Hands

Wash hands thoroughly with soap & water before preparing formula.

Pour desired amount

Pour desired amount of water into the bottle. Add powder.

Shake

Cap bottle and SHAKE WELL.

Use the chart below for correct amounts of water and powder. Use scoop in carton to measure powder. Store DRY scoop in lid holder of the tub.

To Make*WaterPowder
2 fl oz bottle2 fl oz1 unpacked level scoop (8.8 g)
4 fl oz bottle4 fl oz2 unpacked level scoops (17.6 g)
8 fl oz bottle8 fl oz4 unpacked level scoops (35.2 g)

*Each scoop adds about 0.2 fl oz to the amount of prepared formula.

WARNING: Do not use a microwave oven to warm formula. Serious burns may result.

Failure to follow these instructions could result in severe harm. Once prepared, infant formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours.

Do not freeze prepared formula. After feeding begins, use formula within one hour or discard.

Storage/Handling: Store powder at room temperature; avoid extreme temperatures. Refill pouches should only be used with reusable Enfamil Optimum tubs, sold separately. After opening, keep pouch and tub lid tightly closed, store in a dry area, and use contents within 1 month.

Use tub with Enfamil Optimum formula only. Keep powder fresh and prevent bacterial growth by assuring tub is clean and completely dry. When using refill pouches, remove the empty pouch and wipe tub with a clean, dry cloth.

Place new refill pouch inside the tub and keep the powder in the pouch.

Always refer to the batch code and "use by" date on the refill pouch.

USE BY DATE ON BOTTOM OF CARTON OR REFILL POUCH

Last updated: 8/19/25

Enfamil® Optimum™ (Enspire) Infant Formula

Enfamil Optimum Infant Formula 20.5oz
Infant
0-12 months

Feeding needs

Formula benefits

Non-GMONon-GMO

Nutrients

Lactoferrin

See what other parents are saying about
Enfamil® Optimum™ (Enspire) Infant Formula

Overall Rating

4.8
2733 out of 2796 (98%) reviewers recommend this product

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1 to 5 of 3622 Reviews
1 – 5 of 3622 Reviews
5 out of 5 stars.

The best investment for my baby's health.

7 days ago
Great formula with premium ingredients like Lactoferrin. It's gentle on my baby's tummy and mixes easily without clumps. I feel confident knowing it supports brain development and immunity.
Review photo 1.
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influenster.com

Originally posted on influenster.com

Response from Enfamil:
6 days ago
Customer Care
We at Enfamil are so glad you're a part of our family, AnhT! Thanks for taking time to leave a review! — Tasha, Enfamil Expert
Kentucky
GenderFemale
Age25 to 34
How old is your child?0 - 6 months old
4 out of 5 stars.

Better ingredients

8 days ago
Has better ingredients than some. Gentle release doesn't have good ingredients
Where did you purchase the product?Other Online

Yes, I recommend this product.

Helpful?
Response from Enfamil:
6 days ago
Consumer Care Nutrition
Hello Bby1256! We are glad to hear that you have been enjoying using our Enfamil Enspire Optimum! If you have any further questions, please give us a call at 1-800-222-9123, choose option 1, and reference #8051178. Thanks! - Cess, Enfamil Expert
San Antonio, TX
GenderFemale
Age25 to 34
How old is your child?0 - 6 months old
5 out of 5 stars.

Absolutely love!

11 days ago
My supply started to dry up so I had to switch to formula. This is the closest I could get to breastmilk and it has been amazing. She loves it!
Where did you purchase the product?Big box retailer

Yes, I recommend this product.

Helpful?
Response from Enfamil:
9 days ago
Customer Care
We are so happy your little one is loving Enfamil, Steph617. Thank you for taking time to let us know! — Abby, Enfamil Expert
Savannah, Ga
GenderFemale
Age35 to 44
How old is your child?0 - 6 months old
5 out of 5 stars.

Baby loves

14 days ago
Baby boy has been on this since he came home from the hospital, and loves it. I chose this one for its claims to have a key protein that’s found in breast milk. So I felt comfortable giving this to my son since I was unable to breastfeed. He’s now 6 weeks old, happy and thriving.
Where did you purchase the product?Big box retailer

Yes, I recommend this product.

Helpful?
Response from Enfamil:
13 days ago
Customer Care
We are thrilled that your son is doing well on our formula, Britt! Thanks for taking the time to let us know.- Tasha, Enfamil Expert
Houston, TX
How old is your child?0 - 6 months old
5 out of 5 stars.

Love!

20 days ago
We love this formula and that it is closest to breast milk since we dual feed. It is also the third formula we tried and the one that agreed with our son.
Where did you purchase the product?Other Online

Yes, I recommend this product.

Helpful?
Response from Enfamil:
20 days ago
Customer Care
We appreciate your feedback regarding our product, Dani07! Thank you for choosing Enfamil to help give your little guy the best start in life! — Tasha, Enfamil Expert